Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Jordan Gelber Dr. Eugene Hawes Guest Star Ron Canada Manny Rose Guest Star Shiri Appleby Dalit Zirin Guest Star Mather Zickel Hank Prince Guest Star Gretchen Egolf Karen Buckner Guest Star Jason Danieley Barry Granger Guest Star Christina Jackson Nicole Watkins Guest Star Pun Bandhu Lab Assistant Guest Star Adam Grupper Hank's Lawyer Guest Star Ralph Byers Chuck Hammond Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer Bob Goodman Writer Michael Slovis Director