Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor James Frain Odin Reichenbach Actor Tim Guinee Agent McNally Guest Star Wrenn Schmidt Ellory Guest Star Simon Templeman Ronald Adair Guest Star Robert Neary Hernan Zielenko Guest Star Ian Palmer Sean Guest Star Shamika Cotton Rose Guest Star Joan Lunden News Host Guest Star Jonathan Han Arthur Guest Star Robert Doherty Executive Producer, Writer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Christine Moore Director