Goran Visnjic Dr. Luka Kovac Actor Maura Tierney Abby Lockhart Actor Mekhi Phifer Dr. Gregory Pratt Actor Parminder Nagra Dr. Neela Rasgotra Actor Linda Cardellini Nurse Samantha Taggart Actor Shane West Actor Scott Grimes Dr. Archie Morris Actor Laura Innes Dr. Kerry Weaver Actor John Stamos Dr. Tony Gates Actor Stanley Tucci Dr. Kevin Moretti Guest Star Steven Christopher Parker Guest Star Busy Philipps Dr. Hope Bobeck Guest Star Reiko Aylesworth Julia Dupree Guest Star Sam Anderson Dr. Jack Kayson Guest Star Amy Aquino Dr. Janet Coburn Guest Star J.P. Manoux Dr. Dustin Crenshaw Guest Star Laura Cerón Nurse Chuny Marquez Guest Star Troy Evans Frank Martin Guest Star Christopher Chulack Executive Producer Michael Crichton Executive Producer David Zabel Executive Producer John Wells Executive Producer R. Scott Gemmill Executive Producer