Kelsey Grammer Dr. Frasier Crane Actor, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Rita Wilson Mia Preston, Hester Crane Guest Star Georgia Emelin Francesca Guest Star Delaina Mitchell Jessica Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Christopher Lloyd Executive Producer Rob Hanning Writer