Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Penny Johnson Carol Guest Star Sarah Silverman Jane Guest Star Dan Castellaneta Brad Guest Star Valerie Mahaffey Peggy Guest Star Millicent Martin Gertrude Moon Guest Star Missi Pyle Shannon Guest Star T.R. Knight Alex Guest Star Victor Alfieri Esteban de Rojo Guest Star Tim Silva Doorman Guest Star Tom McGowan Kenny Daly Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Chris Marcil Writer