Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Skyler Shaye Guest Star David Veigh Guest Star Laura Carson Guest Star Randall Arney Guest Star Robbie Troy Guest Star Kate Burton Guest Star Moe Irvin Guest Star Lynne Marie Stewart Guest Star Sendhil Ramamurthy Guest Star Richard Gilbert-Hill Guest Star Grinnell Morris Guest Star Kathleen M. Darcy Guest Star Brad Pennington Guest Star Noelle McCutchen Guest Star Gregory Erff Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Peter Horton Director