Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Brent Sexton Guest Star Jonathan Scarfe Guest Star Kathryn Joosten Guest Star Barry Shabaka Henley Guest Star Kate Burton Guest Star Jeff Doucette Guest Star Steven W. Bailey Guest Star Kate Forster Guest Star Moe Irvin Guest Star Jane Morris Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Ann Hamilton Writer John David Coles Director