Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Loretta Devine Guest Star Scott Michael Campbell Guest Star Romy Rosemont Guest Star Lukas Behnken Guest Star Sarah Utterback Guest Star Robin Pearson Rose Guest Star Jim Gleason Guest Star Peter Birkenhead Guest Star Yvette Cruise Guest Star Jeremy Rabb Guest Star David Haley Guest Star Linda Klein Guest Star Seth Adams Guest Star John Cappon Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer, Writer Peter Horton Director