Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor June Lockhart Agnes Guest Star Betty Garrett Eleanor Guest Star Rae Allen Ruth Guest Star Monica Calhoun Mrs. Wood Guest Star Leisha Hailey Claire Solomon Guest Star Kenneth Mitchell Wade Solomon Guest Star Kali Rocha Dr. Sydney Heron Guest Star Steven W. Bailey Joe Guest Star Regine Nehy Cheyenne Wood Guest Star Robin Pearson Rose Patricia Guest Star Sarah Utterback Olivia Harper Guest Star Kate Burton Dr. Ellis Grey Guest Star Zibby Allen Temp Nurse Guest Star Kate Anthony GI Nurse Guest Star Dona Hardy Grace Bickham Guest Star Cathy Lind Hayes Nurse Debbie Guest Star Moe Irvin Nurse Tyler Guest Star Amy Cale Peterson Nurse Home Staffer Guest Star Jeremy Rabb ER Resident Guest Star Pamela Roylance Alice Bickham Guest Star Teddi Siddall Anne Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Zoanne Clack Writer David Paymer Director