Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Christina Ricci Guest Star Kyle Chandler Guest Star Loretta Devine Guest Star Jillian Armenante Guest Star Cress Williams Guest Star Cathy Lind Hayes Guest Star Kathleen M. Darcy Guest Star John Bishop Guest Star Scott Lusby Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Peter Horton Director