Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Eric Dane Guest Star Jeff Perry Guest Star Julio Oscar Mechoso Guest Star Arlene Tur Guest Star Jesse Plemons Guest Star Steven W. Bailey Guest Star Kate Burton Guest Star Gary Carlos Cervantes Guest Star Deborah Geffner Guest Star David Grant Wright Guest Star Brooke Blanchard Guest Star Ariel Felix Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer