Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Chris O'Donnell Guest Star Diahann Carroll Guest Star Richard Roundtree Guest Star Roxanne Hart Guest Star Peter Paige Guest Star Steven W. Bailey Guest Star Elizabeth Sampson Guest Star Javier Grajeda Guest Star Moe Irvin Guest Star Zibby Allen Guest Star Brooke Blanchard Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Krista Vernoff Writer Jeff Melman Director