Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Kevin McKidd Owen Hunt Guest Star Carl Lumbly Guest Star George Newbern Guest Star Colleen Flynn Guest Star Saige Thompson Guest Star Leslie Odom Jr. Guest Star Steven W. Bailey Guest Star Eileen Fogarty Guest Star Rajni Kareer Guest Star Ren Hanami Guest Star Joyce Brew Guest Star Candice Afia Guest Star Amrapali Ambegaokar Guest Star Tymberlee Hill Guest Star Gloria Garayua Guest Star Molly Kidder Guest Star Mark Saul Guest Star Janina Gavankar Guest Star Winston Story Guest Star Joseph Williamson Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Jenna Bans Writer Randy Zisk Director