Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Jessica Capshaw Guest Star Jennifer Westfeldt Guest Star Ben Shenkman Guest Star Peter Mackenzie Guest Star Laura Allen Guest Star Brandon Scott Guest Star Melissa George Guest Star Mary McDonnell Guest Star Susan Merson Guest Star Eric Payne Guest Star Martha Boles Guest Star Lori Harmon Guest Star Mark Saul Guest Star Molly Kidder Guest Star Joseph Williamson Guest Star Winston Story Guest Star Kate Anthony Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer William Harper Writer Julie Anne Robinson Director