Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Kate Walsh Guest Star Audra McDonald Guest Star Taye Diggs Guest Star Grant Show Guest Star Jennifer Westfeldt Guest Star Ben Shenkman Guest Star Laura Allen Guest Star Sam Anderson Guest Star Steven W. Bailey Guest Star Brandon Scott Guest Star Melissa George Guest Star Mark Saul Guest Star Gloria Garayua Guest Star Candice Afia Guest Star Amrapali Ambegaokar Guest Star Tymberlee Hill Guest Star Molly Kidder Guest Star Winston Story Guest Star Joseph Williamson Guest Star Kate Anthony Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Tony Phelan Writer Joan Rater Writer Dan Attias Director