Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor David Morse Michael Tritter Guest Star Pruitt Taylor Vince George Guest Star Stephanie Venditto Nurse Brenda Previn Guest Star Kadeem Hardison Lawyer Howard Gemeiner Guest Star Mary Elizabeth Ellis Sophie Guest Star Cooper Thornton John Guest Star Damien Dante Wayans Haller Guest Star Jim Vickers Folman Guest Star Denver Dowridge Garcia Guest Star Richard Chance Riley Guest Star Bruno Amato Lt. Smith Guest Star Ryan Brockington Rookie Guest Star Michael James Faradie Paramedic 1 Guest Star Alan Frazier Vagrant Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Deran Sarafian Director Thomas L. Moran Writer