Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor Anne Dudek Dr. Amber Volakis Guest Star Edi Gathegi Dr. Jeffrey 'Big Love' Cole Guest Star Peter Jacobson Dr. Chris Taub Guest Star Kal Penn Dr. Lawrence Kutner Guest Star Olivia Wilde Thirteen, Dr. Remy Hadley Guest Star Khleo Thomas Kenny Guest Star Michael Michele Dr. Samira Terzi Guest Star Laurie Fortier Darnell Guest Star Michael Whaley Joe Guest Star Adam Pilver Cranio Surgeon Guest Star Michael Adler E.R. Patient Guest Star David Campbell Plastic Surgeon Guest Star David Um Nakase Physician Guest Star Mandy Schneider Pretty Woman Guest Star Troy Vincent Father Guest Star Lily Howe Jenny Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer David Straiton Director Sean Whitesell Writer