Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor Peter Jacobson Dr. Chris Taub Actor Kal Penn Dr. Lawrence Kutner Actor Olivia Wilde Thirteen, Dr. Remy Hadley Actor Michael Weston Lucas Douglas Guest Star Felicia Day Apple Guest Star Tom Conlon Dr. O'Shea Guest Star Elaine Kagan Frank's Wife Guest Star Melissa Loprire Girl on Street Guest Star Christine Lucas Emma Reed Guest Star Denice Sealy Apple's Nurse Guest Star Tyler Patton Neurosurgeon Guest Star Eric Kaldor Frank Guest Star Aimee Bell Holly the Tennis Player Guest Star Dennis Keiffer Danny Guest Star David Anthony Buglione Rico the Boxer Guest Star Mark Beltzman Tibalt Oyylant Guest Star Michael Gaines Morgan Guest Star Jasmine Alvarez April Reed Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer, Writer Bryan Singer Executive Producer David Straiton Director Lawrence Kaplow Writer