Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor Peter Jacobson Dr. Chris Taub Actor Kal Penn Dr. Lawrence Kutner Actor Olivia Wilde Thirteen, Dr. Remy Hadley Actor Emily Rios Sophia Guest Star Kyle Silverstein Jona Guest Star Alexandra Lydon Melinda Guest Star Nathan Gamble Evan Guest Star Bob McCracken Doug Guest Star Liza Colón-Zayas Maria Guest Star Al Coronel Ray Guest Star Chrissie Fit Girl Guest Star Dawn Frances Nurse Guest Star Yolanda Rubio-Soto Sophia's Mom Guest Star Jose Chavez Sophia's Dad Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer James Hayman Director Pamela Davis Writer Leonard Dick Writer