Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Tony Plana Guest Star Ted Levine Guest Star Richard Cabral Guest Star Floriana Lima Guest Star Michelle Mitchenor Guest Star Christopher T. Wood Guest Star Alex Weed Guest Star Derek Mio Guest Star Luis Moncada Guest Star Ellen Hollman Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer