Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Richard Cabral Guest Star Michelle Mitchenor Guest Star DeRon Horton Guest Star Shashawnee Hall Guest Star Jeannine Kaspar Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer