Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Michelle Mitchenor Guest Star Hilarie Burton Guest Star Chris Tavarez Guest Star Joyful Drake Guest Star Robert Curtis Brown Guest Star Robert Arce Guest Star Michael Harney Guest Star Chin Yere Guest Star James Black Guest Star David Klency Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer Steve Boyum Director Jason Ensler Director Larry Teng Director Antonio Negret Director Rob Seidenglanz Director Michael Fields Director Sylvain White Director Uta Briesewitz Director Nick Copus Director Bethany Rooney Director