Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Joanna "JoJo" Levesque Shaye Guest Star John Ales Phil Guest Star Toby Hemingway Bobby Claypool Guest Star Andrew Creer Zach Bowman Guest Star Hilarie Burton Karen Palmer Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer