Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Valerie Mahaffey Ms. Macelroy Guest Star Rex Linn Principal Petersen Guest Star Brian Stepanek Mr. Givens Guest Star Dave Florek Dr. Eberland Guest Star Pam Cook Diane Guest Star Kurt Doss Ned Guest Star Katherine Von Till Local Newscaster Guest Star Monica Garcia Coughing Teacher Guest Star James Sklena Detention Student 1 Guest Star Christopher Griffin Detention Student 2 Guest Star Stone Eisenmann Detention Student 3 Guest Star Hannah Eisenmann Detention Student 4 Guest Star Caitlin Carmichael Veronica Guest Star Amanda Pearl Bell Vanessa Guest Star Eloise Jacott Robin Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Eric Kaplan Writer Jeremy Howe Writer Howard Deutch Director