Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Valerie Mahaffey Ms. Macelroy Guest Star Danielle Pinnock Ms. Ingram Guest Star Doc Farrow Coach Wilkins Guest Star Vernee Watson Nurse Robinson Guest Star Wayne Wilderson Dr. Gilbert Guest Star Mauricio Lara Ricky Guest Star Nick Alvarez Derek Guest Star Chris Flanders Gary Guest Star Kiva Jump Daisy Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Tara Hernandez Writer Jeremy Howe Writer Connor Kilpatrick Writer Mark Cendrowski Director