Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Wallace Shawn Dr. John Sturgis Guest Star Rex Linn Principal Petersen Guest Star Danielle Pinnock Ms. Ingram Guest Star Doc Farrow Assistant Coach Wilkins Guest Star Melissa Peterman Brenda Sparks Guest Star Billy Sparks Wyatt McClure Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer Todd Spiewak Executive Producer