Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Matt Hobby Pastor Jeff Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Mary Grill Officer Robin Guest Star Steve Burns Nathan Guest Star J. Rene Pena Caroline Guest Star Ava Allan Jana Guest Star Doug Cox Pastor Dave Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Maria Ferrari Writer Tara Hernandez Writer Jeremy Howe Writer Yael Glouberman Writer Alex Reid Director