Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Melissa Peterman Brenda Sparks Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Isabel May Veronica Guest Star Ava Allan Jana Guest Star Louie Anderson Ralph Guest Star Lyn Alicia Henderson Sally Guest Star Stacey Moseley Carol Guest Star Magnus Chhan Student Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Maria Ferrari Writer Tara Hernandez Writer Jeremy Howe Writer Connor Kilpatrick Writer Melissa Joan Hart Director