Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Melissa Peterman Brenda Sparks Guest Star Reba McEntire June Guest Star Doc Farrow Coach Wilkins Guest Star Mckenna Grace Paige Guest Star Wendie Malick President Hagemeyer Guest Star Andrea Anders Linda Guest Star Aldo Quintino Nick Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Tara Hernandez Writer Jeremy Howe Writer Connor Kilpatrick Writer Marie Cheng Writer Melissa Joan Hart Director