Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Craig T. Nelson Dale Guest Star Melissa Peterman Brenda Guest Star Wyatt McClure Billy Guest Star Doc Farrow Coach Wilkins Guest Star Donna Pieroni Female Patron Guest Star Polina Frantsena Girl #1 Guest Star Brittini London Girl #2 Guest Star Samantha Cutaran Girl #3 Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Eric Kaplan Writer Connor Kilpatrick Writer Nadiya Chettiar Writer Yael Glouberman Writer Jeremy Howe Director