Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Ed Begley Jr. Professor Linkletter Guest Star Nancy Linehan Charles Peg Guest Star Jared Wernick Clark Guest Star Ben Stillwell Lyle Guest Star Mary Kate Wiles Patricia Guest Star Nikea Gamby-Turner Florence Guest Star Zachary Alexander Rice Zach Guest Star Denisse Ojeda Melissa Guest Star Valerie Gutierrez Student #1 Guest Star Edwin Kho Student #3 Guest Star Kiana Thompson Student #2 Guest Star Stephen Hawking Self Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Nick Bakay Writer Connor Kilpatrick Writer Steve Holland Writer Eric Kaplan Writer Nadiya Chettiar Writer Alex Reid Director