Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Jason Alexander Gene Lundy Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Wendie Malick President Hagemeyer Guest Star Steve Burns Nathan Guest Star Melissa Peterman Brenda Guest Star Brian Stepanek Mr. Givens Guest Star Sarah Baker Ms. Hutchins Guest Star Nancy Linehan Charles Peg Guest Star Jackie Geary Ann Guest Star Stephanie Escajeda Betty Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Nick Bakay Writer Yael Glouberman Writer Eric Kaplan Writer Nadiya Chettiar Writer