Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Doc Farrow Coach Wilkins Guest Star Dan Byrd Pastor Rob Guest Star Wendie Malick President Hagemeyer Guest Star Emily Osment Mandy Guest Star Wyatt McClure Billy Guest Star Grady Lee Richmond Wade Guest Star Griffin McIntyre Danny Guest Star Giovannie Espiritu Nurse Guest Star Emily Bolt Wife Guest Star Preston Greer Husband Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Nick Bakay Writer Connor Kilpatrick Writer Marie Cheng Writer Steve Holland Writer Jeremy Howe Director