Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Ed Begley Jr. Dr. Linkletter Guest Star Penn Jillette A.V. Guest Star Teller Pus Guest Star Melissa Peterman Brenda Guest Star Doc Farrow Coach Wilkins Guest Star Rex Linn Principal Petersen Guest Star Wendie Malick President Hagemeyer Guest Star Grady Lee Richmond Wade Guest Star Drew Powell Roy Guest Star Michelle Meredith Wendy Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Eric Kaplan Writer Yael Glouberman Writer Nick Bakay Writer Nadiya Chettiar Writer Alex Reid Director