Chuck Lorre Creator, Executive Producer Steven Molaro Creator, Executive Producer, Writer Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Emily Osment Mandy Actor Wallace Shawn Dr. Sturgis Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Melissa Peterman Brenda Guest Star Wyatt McClure Billy Guest Star Todd Spiewak Executive Producer Steven Holland Writer Eric Kaplan Writer Nadiya Chettiar Writer Jeremy Howe Writer Connor Kilpatrick Writer Shiri Appleby Director