Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Emily Osment Mandy Actor Craig T. Nelson Dale Guest Star Melissa Peterman Brenda Guest Star Lucy Loken Amber Guest Star Stacie Greenwell Helen Guest Star Zabeth Russell Jill Guest Star Zane Moyer Ryan Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer Todd Spiewak Executive Producer Steven Holland Writer Nick Bakay Writer Jeremy Howe Writer Steve Molaro Writer Eric Kaplan Writer Connor Kilpatrick Writer Jaffar Mahmood Director