Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Emily Osment Mandy Actor Wallace Shawn Dr. Sturgis Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Wendie Malick President Hagemeyer Guest Star Dave Foley Gary Guest Star Rachel Bay Jones Audrey Guest Star Grady Lee Richmond Wade Guest Star Hermie Castillo Toby Guest Star Karen Y. McClain Doreen Guest Star Jim Meskimen Dr. Nicholson Guest Star Tom Ayers Bradley Guest Star Jill Basey Barbara Guest Star Roger J. Timber Carlos Guest Star Kenzo Lee Carl Guest Star Wes Martinez Delivery Man Guest Star Raphael Vargas Chestang Robert Guest Star Matthew Thorson Benavides Charlie Guest Star Celestial Eileen Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer Todd Spiewak Executive Producer Steve Molaro Writer Eric Kaplan Writer Nadiya Chettiar Writer Steven Holland Writer Jeremy Howe Writer Marie Cheng Writer Alex Reid Director