Nathan Fillion Richard Castle Actor Stana Katic NYPD Captain Kate Beckett Actor Susan Sullivan Martha Rodgers Actor Molly C. Quinn Alexis Castle Actor Ruben Santiago-Hudson Captain Roy Montgomery Actor Tamala Jones Lanie Parish Actor Jon Huertas NYPD Detective Javier Esposito Actor Seamus Dever NYPD Detective Kevin Ryan Actor Debi Mazar Paula Haas Guest Star Reed Diamond Dr. Cameron Talbot Guest Star Elaine Hendrix Melissa Talbot Guest Star Dianna Maria Riva Detective Roselyn Karpowski Guest Star Arye Gross M.E. Sidney Perlmutter Guest Star Ivo Nandi Teodor Hajek Guest Star Jeff Doucette Super Guest Star Timi Prulhiere Talbot's Nurse Guest Star Griffin Cleveland Zane Talbot Guest Star Francisco Viana Manager Guest Star Andrew W. Marlowe Executive Producer Armyan Bernstein Executive Producer Barry Schindel Executive Producer Rob Bowman Executive Producer Laurie Zaks Executive Producer René Echevarria Writer John Terlesky Director