Gary Sinise Det. Mack "Mac" Taylor Actor Melina Kanakaredes Det. Stella Bonasera Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Vanessa Ferlito Aiden Burn Actor Eddie Cahill Det. Donald Flack, Jr. Actor Ron Yuan Dr. Evan Zao Actor David Julian Hirsh Zack Shannon Guest Star Ed Quinn Frankie Mala Guest Star John Dove Det. John Scagnetti Guest Star Larry Poindexter Dr. Stanley Thatcher Guest Star Laird Macintosh Dr. Spencer Howard Guest Star Todd Stashwick Ira Feinstein Guest Star Francis Guinan Ron Miller Guest Star Paul Wesley Steve Samprass Guest Star Jay Kenneth Johnson Paul Deacon Guest Star Sonia Maria Martin Evelyn Danner Guest Star Casey McCarthy Melanie Hampton Guest Star Steve Paymer Donald Scott Guest Star Lauren Bowles Jamie Blake Guest Star Leroy Edwards III Guest Star John Cappon Guest Star Aria Wallace Guest Star Sarah Scherger Guest Star Renee Darmiento Guest Star Scott Elrod Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Scott Lautanen Director Zachary Reiter Writer