Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Nelsan Ellis Shinwell Johnson Actor Stephen Rider Tyus Wilcox Guest Star Al Thompson Bonzi Folsom Guest Star Joanna Christie May Guest Star Chris McKinney Detective Guzman Guest Star Ruffin Prentiss Laquan Eversley Guest Star Clark Jackson Nelson Lewis Guest Star Daryl Edwards Detective Perkins Guest Star Toni Ann DeNoble Rochelle Guest Star Adrian Alvarado Uniform 1 Guest Star Lilli Cooper Female EMT Guest Star Megan Byrne Doctor Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer, Writer Christine Moore Director