Michael Crichton Creator Anthony Edwards Dr. Mark Greene Actor George Clooney Dr. Doug Ross Actor Sherry Stringfield Dr. Susan Lewis Actor Eriq La Salle Dr. Peter Benton Actor Noah Wyle Dr. John Carter Actor Julianna Margulies Head Nurse Carol Hathaway Actor Abraham Benrubi Jerry Markovic Guest Star Rick Rossovich Dr. John 'Tag' Taglieri Guest Star Sam Anderson Dr. Jack Kayson Guest Star Khandi Alexander Jackie Robbins Guest Star Zachary Browne Jake Leeds Guest Star William H. Macy Guest Star Ming-Na Wen Jing-Mei Chen Guest Star Lisa Zane Diane Leeds Guest Star Gloria Reuben Jeanie Boulet Guest Star Alexis Cruz Terry Guest Star Trenton Knight Zachary Guest Star Darryl Fong Mr. Chang Guest Star Walter Addison Mr. Kane Guest Star