Anthony Edwards Dr. Mark Greene Actor George Clooney Dr. Doug Ross Actor Sherry Stringfield Dr. Susan Lewis Actor Eriq La Salle Dr. Peter Benton Actor Noah Wyle Dr. John Carter Actor Julianna Margulies Head Nurse Carol Hathaway Actor Gloria Reuben Jeanie Boulet Actor Red Buttons Jules 'Ruby' Rubadoux Guest Star Tim DeZarn Mr. Krawczyk Guest Star Jessica Steen Karen Hardy Guest Star Yvette Freeman Nurse Haleh Adams Guest Star Richard Penn Dave Donovan, DCFS Guest Star Eileen Ryan Barbara Dean Guest Star Ron Rifkin Guest Star Christine Harnos Guest Star CCH Pounder Dr. Angela Hicks Guest Star William H. Macy Dr. David Morgenstern Guest Star Michael Crichton Executive Producer John Wells Executive Producer