Kelsey Grammer Dr. Frasier Crane Actor John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Nicholas Walker Francois Guest Star John Cusack Greg Guest Voice David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Christopher Lloyd Executive Producer Jeff Melman Director Michael B. Kaplan Writer