Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Alan Tudyk Todd Peterson Guest Star Jane Adams Dr. Mel Karnofsky Guest Star Tom McGowan Kenny Daly Guest Star James Whitson Andrew Guest Star Elizabeth Alley Margaret Guest Star Sean Smith Chip Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Katy Garretson Director Gayle Abrams Writer