Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Jean Smart Lana Gardner Guest Star Patrick Breen Phillip Guest Star Tom Verica Jim Guest Star Mary-Joan Negro Joanne Guest Star Gloria LeRoy Mrs. Smolenski Guest Star Biff McGuire Mr. Smolenski Guest Star Mark Durbin David Hicks Guest Star Cyndi Martino Board Member Guest Star Steve Stapenhorst Board Member Guest Star Mark Withers Board Member Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Eric Zicklin Writer Lori Kirkland Baker Writer