Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Millicent Martin Gertrude Moon Guest Star Harve Presnell Mike Shaw Guest Star Ann Cusack Antonia Guest Star Paul Schulze Alex Guest Star Scotch Ellis Loring Jeremy Guest Star Matthew Yang King Thad Guest Star Ashley Thomas Alice May Doyle Guest Star Christopher Lawford Bill Guest Star Nana Visitor Sharon Guest Star Booth Colman Mr. Slobodkin Guest Star Michael Weston Ice Sculptor Guest Star Joshua Fardon Luke Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Katy Garretson Director Heide Perlman Writer