Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Wendie Malick Ronee Lawrence Guest Star Estelle Parsons Opal Guest Star Gabrielle Miller Willa Haver Guest Star Jack Laufer Roland Guest Star Linda Gehringer Sarah Guest Star Bernadette Birkett Janelle Guest Star Phyllis Flax Florence Guest Star Helen Mirren Babette the Caller Guest Voice David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Heide Perlman Writer