Sophia Bush Dr. Sam Griffith Actor Jason Isaacs Dr. Rob "Griff" Griffith Actor, Director Skye P. Marshall Dr. Lex Trulie Actor Michael Stahl-David Dr. Caleb Tucker Actor Davi Santos Dr. Joey Costa Actor Omar Maskati Dr. Isan M. Shah Actor Wendy Crewson Vivian Katz Actor Edwin Hodge Malcolm A. Kingsley Actor Sendhil Ramamurthy Asher Pyne Guest Star Victoria Rowell Tina Kingsley Guest Star Marium Carvell Nurse Donna Williams Guest Star Stephen Tracey Tim Davis Guest Star Travis Van Winkle Dr. Eric Kace Guest Star Evan Parke Byron Kingsley Guest Star Gerardo Celasco Dr. Nick Vega Guest Star Jeff Clarke Johnny Deane Guest Star Tammy Isbell Susan Dean Guest Star Hannah Galway Chloe Guest Star Sydney Kuhne Yolanda Guest Star Ipsita Paul Gladys Bridges Guest Star Anita Sarda Board Member Guest Star Katie Wech Executive Producer Jennie Snyder Urman Executive Producer Joanna Klein Executive Producer Frank Siracusa Executive Producer John Weber Executive Producer Lydia Teffera Writer Jeremy Svenson Writer