Blake Lively Serena van der Woodsen Actor Leighton Meester Blair Waldorf Actor Penn Badgley Dan Humphrey Actor Chace Crawford Nate Archibald Actor Ed Westwick Chuck Bass Actor Kaylee Defer Charlie Rhodes, Charlie Rhodes Actor, Guest Star Kelly Rutherford Lily van der Woodsen Actor Matthew Settle Rufus Humphrey, Rufus Humphrey Actor, Guest Star Michael Michele Guest Star Elizabeth Hurley Guest Star Hugo Becker Guest Star Zoe Bell Guest Star Jenny Lewis Guest Star Johnathan Rice Guest Star Josh Schwartz Executive Producer Stephanie Savage Executive Producer Leslie Morgenstein Executive Producer Bob Levy Executive Producer Joshua Safran Executive Producer, Writer Mark Piznarski Director