Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kevin Rahm Guest Star Sarah Hagan Guest Star Joan McMurtrey Guest Star Josh Stamberg Guest Star Steven W. Bailey Guest Star Ping Wu Guest Star Charles Walker Guest Star Chad Einbinder Guest Star Lisa Kaminir Guest Star Kathleen Bailey Guest Star Darlene Kegan Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Mimi Schmir Writer Sarah Pia Anderson Director